Stadium: Cameron Indoor Stadium
Home Manager: Jon Scheyer Away Manager: Dave Dickerson
| NCAAB | 2022/03/22 00:00 | USC Upstate v South Alabama | L | 79-83 |
| NCAAB | 2022/03/15 22:30 | USC Upstate v Appalachian State | W | 80-74 |
| NCAAB | 2022/03/05 17:00 | USC Upstate v Longwood | L | 70-79 |
| NCAAB | 2022/03/04 19:30 | Charleston Southern v USC Upstate | W | 62-72 |
| NCAAB | 2022/02/26 21:00 | Gardner Webb v USC Upstate | W | 70-72 |
| NCAAB | 2022/02/25 00:00 | USC Upstate v Winthrop | L | 59-89 |
| NCAAB | 2022/02/19 22:30 | USC Upstate v Charleston Southern | W | 78-73 |
| NCAAB | 2022/02/16 23:00 | Presbyterian v USC Upstate | W | 55-60 |
| NCAAB | 2022/04/03 00:49 | North Carolina v Duke | L | 81-77 |
| NCAAB | 2022/03/27 00:49 | Arkansas v Duke | W | 69-78 |
| NCAAB | 2022/03/25 01:39 | Texas Tech v Duke | W | 73-78 |
| NCAAB | 2022/03/20 21:15 | Michigan State v Duke | W | 76-85 |
| NCAAB | 2022/03/18 23:10 | CS Fullerton v Duke | W | 61-78 |
| NCAAB | 2022/03/13 01:30 | Virginia Tech v Duke | L | 82-67 |
| NCAAB | 2022/03/12 00:00 | Miami Florida v Duke | W | 76-80 |
| NCAAB | 2022/03/10 17:00 | Syracuse v Duke | W | 79-88 |