[20] BUF Sabres 1-3 OTT Senators [24] 2022-10-17 08:00
Stadium: Canadian Tire Centre
Home Manager: Away Manager: Don Granato
Head to Head
| NHL | 2022/10/13 23:00 | OTT Senators v BUF Sabres | W | 1-4 |
| NHL | 2022/02/18 00:00 | OTT Senators v BUF Sabres | L | 3-1 |
| NHL | 2022/01/26 00:00 | BUF Sabres v OTT Senators | L | 0-5 |
| NHL | 2022/01/19 00:00 | BUF Sabres v OTT Senators | W | 3-1 |
| NHL | 2020/02/19 00:30 | BUF Sabres v OTT Senators | L | 4-7 |
| NHL | 2020/01/29 00:00 | OTT Senators v BUF Sabres | L | 5-2 |
| NHL | 2019/12/24 00:30 | BUF Sabres v OTT Senators | L | 1-3 |
| NHL | 2019/11/17 00:00 | OTT Senators v BUF Sabres | W | 2-4 |
Home History
| NHL | 2022/10/15 17:00 | FLA Panthers v BUF Sabres | L | 4-3 |
| NHL | 2022/10/13 23:00 | OTT Senators v BUF Sabres | W | 1-4 |
| NHL Pre-Season | 2022/10/07 23:00 | BUF Sabres v PIT Penguins | L | 1-7 |
| NHL Pre-Season | 2022/10/04 23:00 | CAR Hurricanes v BUF Sabres | W | 2-4 |
| NHL Pre-Season | 2022/10/01 17:00 | PIT Penguins v BUF Sabres | W | 1-3 |
| NHL Pre-Season | 2022/09/28 23:00 | BUF Sabres v CLB Blue Jackets | L | 1-4 |
| NHL Pre-Season | 2022/09/27 23:00 | PHI Flyers v BUF Sabres | W | 1-2 |
| NHL Pre-Season | 2022/09/25 18:00 | BUF Sabres v WAS Capitals | W | 4-3 |
Away History
| NHL | 2022/10/15 23:00 | OTT Senators v TOR Maple Leafs | L | 2-3 |
| NHL | 2022/10/13 23:00 | OTT Senators v BUF Sabres | L | 1-4 |
| NHL Pre-Season | 2022/10/08 22:30 | MTL Canadiens v OTT Senators | W | 2-3 |
| NHL Pre-Season | 2022/10/06 22:00 | OTT Senators v MTL Canadiens | W | 4-3 |
| NHL Pre-Season | 2022/10/04 23:00 | OTT Senators v MTL Canadiens | W | 5-4 |
| NHL Pre-Season | 2022/10/01 23:00 | MTL Canadiens v OTT Senators | W | 4-5 |
| NHL Pre-Season | 2022/09/30 23:00 | TOR Maple Leafs v OTT Senators | L | 6-3 |
| NHL Pre-Season | 2022/09/28 00:00 | OTT Senators v WPG Jets | L | 3-5 |